Tekalegn Mitiku2026-02-052024-05https://etd.hu.edu.et/handle/123456789/660This work studied the production cross section and yield of medically important radionuclides, such as 68Ga and 64Cu, generated during irradiation of 66Zn-target with α-projectile at ≈ 10-40 v MeV. The experimental cross-sections taken from the EXFOR database were compared with the theoretical model calculations using nuclear reaction model codes COMPLETE, TALYS1.95 (G), and EMPIRE3.2. A good agreement was achieved for the measured data and calculated production cross-section using the TALYS1.95 (G) code. The 68Ga and 64Cu yields were computed using TALYS1.95 (G) predicted cross-section data. Also, the possible isotopic impurities were identified, and their contributions were estimated. Based on the yield calculations, the production yield of 68Ga was found to be 39.6 GBq/μAh, at 28 MeV without any significant contribution from its isotopic impurities 67Ga and 66Ga; in addition a yield value of 85.9 MBq/μAh at 40 MeV was obtained for medically important 64Cu radionuclide with negligible isotopic impurities contributions from 66Cu and 62Cu radionuclidesen-USThesis